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Browsing Akademik Merkezler / Academic Centers by Author "Aktürk, Tuba"

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    Cognitive Impairment in Parkinson's Disease Is Reflected with Gradual Decrease of EEG Delta Responses during Auditory Discrimination
    (Frontiers Media Sa, Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland, 2018-02-21) Güntekin, Bahar; Hanoğlu, Lütfü; Güner, Dilan; Helvacı Yılmaz, Nesrin; Çadırcı, Fadime; Mantar, Nagihan; Aktürk, Tuba; Emek Savaş, Derya Durusu; Özer, Fahriye Feriha; Yener, Görsev G.; BAŞAR, EROL; 204666; 171122; 194489; 259227; 259226; 275116; 227002; 38782; 143760; 142226
    Parkinson's disease (PD) is a neurodegenerative disease that is characterized by loss of dopaminergic neurons in the substantia nigra. Mild Cognitive impairment (MCI) and dementia may come along with the disease. New indicators are necessary for detecting patients that are likely to develop dementia. Electroencephalogram (EEG) Delta responses are one of the essential electrophysiological indicators that could show the cognitive decline. Many research in literature showed an increase of delta responses with the increased cognitive load. Furthermore, delta responses were decreased in MCI and Alzheimer disease in comparison to healthy controls during cognitive paradigms. There was no previous study that analyzed the delta responses in PD patients with cognitive deficits. The present study aims to fulfill this important gap. 32 patients with Parkinson's disease (12 of them were without any cognitive deficits, 10 of them were PD with MCI, and 10 of them were PD with dementia) and 16 healthy subjects were included in the study. Auditory simple stimuli and Auditory Oddball Paradigms were applied. The maximum amplitudes of each subject's delta response (0.5-3.5 Hz) in 0-600 ms were measured for each electrode and for each stimulation. There was a significant stimulation x group effect [F(df = 6; 88 = 3,21; p < 0.015; eta(2)(p) = 0.180], which showed that the difference between groups was specific to the stimulation. Patients with Parkinson's disease (including PD without cognitive deficit, PD with MCI, and PD with dementia) had reduced delta responses than healthy controls upon presentation of target stimulation (p < 0.05, for all comparisons). On the other hand, this was not the case for non-target and simple auditory stimulation. Furthermore, delta responses gradually decrease according to the cognitive impairment in patients with PD. Conclusion: The results of the present study showed that cognitive decline in PD could be represented with decreased event related delta responses during cognitive stimulations. Furthermore, the present study once more strengthens the hypothesis that decrease of delta oscillatory responses could be the candidate of a general electrophysiological indicator for cognitive impairment.
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    Delta oscillatory responses as a general electrophysiological biomarker for cognitive disorders
    (Elsevier Science Bv, Po Box 211, 1000 AE Amsterdam, Netherlands, 2016-10) Güntekin, Bahar; Hanoğlu, Lütfü; Aktürk, Tuba; Dilan, Güner; Turp Gölbaşı, Bilge; Yener, Görsev G.; BAŞAR, EROL; 204666; 171122; 275116; 143760; 142226
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    Hallucinations in Parkinson's Disease are represented with increased EEG-Gamma band activity
    (Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ USA, 2017-12) Uysal Kaba, Reyyan; Hanoğlu, Lütfü; Helvacı Yılmaz, Nesrin; Aktürk, Tuba; Güner, Dilan; Güntekin, Bahar; BAŞAR, EROL; 262883; 171122; 194489; 275116; 142226; 204666