Advances in Molecular Biology / Moleküler Biyolojide Gelişmeler

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Browsing Advances in Molecular Biology / Moleküler Biyolojide Gelişmeler by Author "ARISAN, ELİF DAMLA"

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    PublicationOpen Access
    Antioxidant enzyme profile in chronic pelvic pain syndrome patients
    (İstanbul Kültür Üniversitesi Yayınları, 2007-03) Arısan, Serdar; Kiremit, Murat Can; Palavan-Ünsal, Narçin; Ergenekon, Erbil; ARISAN, ELİF DAMLA
    Chronic pelvic pain syndrome (CPPS) is a common and serious health problem affecting the quality of life in men. According to National Institute of Health classification system abacterial chronic pelvic pain has two sub category which are defined as 3a and 3b. The major difference between these two groups inflammation status. In this study we aim to investigate the antioxidant enzyme levels such as Glutathion peroxidase (Gsh-Px), superoxide dismutase (SOD), catalase (CAT) and lipid peroxidation products in CPPS patients. All enzyme levels were determined in patients and disease free control group blood samples by spectrophotometrically. In our study, the enzyme levels were not a good indicator for comparison of 3a or 3b type CPPS patients. However, Gsh-Px, SOD and lipid peroxidation products were significantly different from disease free control samples. Although high generation of H202 due to SOD activity, we did not detect any change in CAT activity in patients blood samples compare to control group.
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    PublicationOpen Access
    Resveratrol: Chemoprevention with red wine
    (İstanbul Kültür Üniversitesi, 2007-03) Palavan-Ünsal, Narçin; ARISAN, ELİF DAMLA
    According to epidemiological studies, western diet has disadvantages because of cancer prevalence more than Mediterranean or Asia people who consume more vegetables and fruits. Resveratrol (trans-3,4,5-trihydroxystilbene) which is highly found in grapes, berries has received attention for its potential chemopreventive and antitumor effects in experimental systems. Because of high resveratrol content, researchers noted that red wine has multidimensional benefits for cardiovascular health. Resveratrol also protects neuron cells from other well known chemotherapeutics. The molecular function of resveratrol in chemoprevention and carcinogenesis are reviewed by experimental cancer cell models. Resveratrol is going to be a promising molecule in future cancer prevention and therapy models.
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    PublicationOpen Access
    Therapeutical potential of mitochondrial reactive oxygen species in carcinogenesis
    (İstanbul Kültür Üniversitesi, 2009) Palavan-Ünsal, Narçin; ARISAN, ELİF DAMLA
    Mitochondria is a gatekeeper of cell death with dual function in survival and death decision. Mitochondria is also an important center for reactive oxgen species (ROS) production within most mammalian cells. The bulk of mitochondrial ROS generation can occur at relatively high rates compared to cytosolic ROS production and is primarily determined by metabolic conditions. This event contributes to mitochondrial damage in a range of pathologies and is also important in redox signalling from the organelle to the rest of the cell. Mitochondria targetting strategies in the therapeutical options are promising to increase the ROS generation to induce the apoptosis in cancer cells. Identification of molecular basis of therapeutic potential of mitochondrial ROS generation may provide more successful therapeutic tools in cancer therapy.